May
2007
Obesity & Fructose
Obesity and fructose - how are they related? 2/3 of Americans are overweight or obese. It is getting worse the past couple of decades. High fructose is very common over the past couple of decades as well. High fructose is added to most sweet drinks and foods.
Fructose is a simple sugar similar in structure to glucose (the main sugar). Metabolism is
unique – mostly done by the gut organs. Digested into glucose, glycogen, lactate, or lipids. Does use insulin – so initially was studied in type II diabetics to see if was good alternative to sugar (glucose or sucrose). Initially digested appeared to be beneficial. Low dose fructose increase glucokinase and lowers liver production of glucose.
However, later in metabolism shown to associate with Metabolic Syndrome X: insulin resistance (diabetes or glucose intolerance) , bad cholesterol (high LDL and triglycerides), increased body fat, and high blood pressure. Increased uric acid as well that increases risk of gout and kidney stones. Nurses’ Health Study 1999 showed high-fructose correlated with high c-peptide levels (~insulin). Stimulates sympathetic nervous system which is why people might get a “boost” with high sugar/fructose.
Unlike sucrose (2 glucoses combined), fructose doesn’t signal to brain that the body is full – so overeating is common. High-fructose corn syrup in mice – drink more of this than sucrose sweetened water
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drjohnhong 
Uncategorized, obesity, diabetes, food, weight 
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