July
2008
Menopause
Menopause: cessation of menstrual periods. For 12 months. Mean age 51.4 years old. 5% start 40-45yo & 5% after 55yo. <40yo premature ovarian failure. STRAW staging system: -5 to +2. -5 to -3 is reproductive stage. Menopause transition: -2 early, -1 late. 0 is menopause . +1 early postmenopause. +2 late postmenopause. Early menopause transition: variable cycle length greater than 7 days change from normal (which is 21-35d). Follicular phase shortens, inhibin B falls, FSH rises. Estradiol is normal to high still from increased aromatase activity but lower progesterone in luteal phase.Late menopause transition: 2 or more skipped cycles and no periods 60 or more days. Often hot flashes occur. FSH spikes but then drops to normal.Menopause: 12mo no periods after the final period. Ovaries stop ovulating and secreting estrogen. Early menopause: first 5 yrs after final menstrual period. Accelerated bone loss and ovarian failure. hot flashes common. Late menopause: after 5 years to death.
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