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28
November
2007

Fecal Incontinence

Fecal Incontinence:  #2 cause of nursing home placement.  Adult diapers in 1988 $400 million in USA.  This means an adult accidentally poops at least once a month.  Minor fecal incontinence is while passing gas (flatulence/farting) some stool comes our, or a person has loose stools (like in diarrhea) and it comes out accidentally.  Major fecal incontinence means feces comes out unwillingly.

Who knows how many people have fecal incontinence because most people are too embarrassed to admit to it.  It is estimated to affect 11-15% of community-dwelling adults (like nursing homes, assisted living)

Risk factors: age, obesity, COPD, IBS, urinary incontinence, colectomy, mentation.  Men and women have the same prevalence, but women are 2x more likely to admit to it. People with brain injury often have fecal incontinence.  After childbirth, trauma to the anal sphincter or pudendal nerve can cause fecal incontinence for years.  Surgeries such as for hemorrhoids & anal fistulas can lead to fecal incontinence.  Rectal prolapse is risk. Diabetics with autonomic neuropathy, bacterial overgrowth syndrome, and reduced sphincter pressure can have fecal incontinence.  History of radiation therapy can lead to proctitis.  Ulcerative proctitis as well. Some cannot sense stool in the rectum: diabetics, MS, dementia, spinal cord injuries. With fecal impactions, liquid stool can seep around the hard stool and out the anus in elderly.

Continence relies on many factors.  The bottom line is when stool stretches the rectum, the   person should sense this.  To poop or not poop is based on relaxing or not relaxing the external anal sphincter muscles.

Work up:  history and physical examination by doctor. Endoscopy is often needed. Anorectal manometry measures the function of the anus and rectum which can give valuable information. Pudendal nerve terminal latency test, endorectal ultrasound, defecography, and EMG can be done.

Treatment: Medical therapy, biofeedback, and surgery. Depends on the underlying causes.

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22
November
2007

Fungal Skin Infections

See the lovely fungus

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14
November
2007

New Type II Diabetes Pill: Januvia

Type 2 Diabetes means the body is resistant to insulin. The body makes insulin, but usually due to obesity the body doesn’t respond to insulin well anymore. So the pancreas cranks out more and more insulin to compensate for this need, but in time it is not enough.

Over 7% American adults have diabetes. Since 1990 Type II diabetes has been dramatically increasing in children and adolescents due to obesity. 14% of US health care costs are from diabetes. Overall costs to USA is about 132 billion dollars as of 2002. Fasting blood glucose of 126 or more is diabetes, or a HbA1C of 6% or more.

So, Januvia (sitagliptin) has been out in the market for over the past year to help those with Type II diabetes who aren’t getting enough control on metformin (a commonly used medicine for type 2 diabetes). So what is it? Oh, boy, here is my best explanation.

Incretins are intestinal hormones that are released when there is food in the gut. Incretins GLP-1 (glucoagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) do the following: lowers glucagon secretion, slows the GI system, and increases satiety. Also they stimulate secretion of insulin

Dipeptidyl peptidase-4 (DDP-4) “digests” GLP-1 and GIP, so Januvia inhibits

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7
November
2007

AIDS 2007

How has AIDS changed in the past 26 years?

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